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Pyrroloquinoline quinone (PQQ) is a peptide-derived redox cofactor produced by prokaryotes that also plays beneficial roles in organisms from other kingdoms. We review recent developments on the pathway of PQQ biogenesis, focusing on the mechanisms of PqqE, PqqF/G, and PqqB. These advances may shed light on other, uncharacterized biosynthetic pathways. Copyright © 2020 Elsevier Ltd. All rights reserved.


Wen Zhu, Judith P Klinman. Biogenesis of the peptide-derived redox cofactor pyrroloquinoline quinone. Current opinion in chemical biology. 2020 Dec;59:93-103

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PMID: 32731194

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