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    Molecular imaging enables noninvasive visualization of cancer-related biological processes for tumor diagnostics; engineering molecular probes for accurate and efficient tumor imaging remains challenge. Herein, by using a biosynthetic strategy, we prepared a tumor-targeted fluorescence/magnetic resonance protein-based probe for dual-modal imaging. The probe was biosynthesized by the fusion of targeting peptide (RGD) with fluorescence protein (RFP) and a small peptide (LBT) that had strong affinity with Gd3+. The probe showed excellent RGD-mediated tumor targeting and stable infrared emission, enabling sensitive tumor-specific imaging. Moreover, efficient T1-weighted magnetic resonance imaging was observed both in vitro and at tumor sites, facilitating high spatial resolution tumor imaging. The simultaneous dual-modal imaging provided more complementary information than each imaging modality. Our work demonstrates the capability of biosynthetic strategy to engineer molecular imaging probes for tumor-targeted multimodal bioimaging, and the probes can be customized to precisely localize and monitor other types of diseases. Copyright © 2020 Elsevier Ltd. All rights reserved.


    Huaixin Zhao, Huiting Zhao, Yi Jiao, Yi Zhu, Chunxia Liu, Feng Li, Yinsong Wang, Zi Gu, Dayong Yang. Biosynthetic molecular imaging probe for tumor-targeted dual-modal fluorescence/magnetic resonance imaging. Biomaterials. 2020 Oct;256:120220

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    PMID: 32736168

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