Dunaimycin C3, a new GRP78 downregulator from Streptomyces sp. RAN389.

Yoichi Hayakawa, Tomohiro Yoshida, Shoko Kimata, Kazuo Shin-Ya

The Journal of antibiotics 2021 Jan

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A new member of the dunaimycin family, dunaimycin C3 (2), was isolated from a fermented broth of Streptomyces sp. RAN389. The molecular formula of 2 was established as C42H70O10 by high-resolution FAB-MS, and the structure was elucidated by NMR spectroscopic analyses. Dunaimycin C3 inhibited the expression of the molecular chaperone GRP78 in HT1080 G-L cells in the presence of 10 mM of 2-deoxyglucose with an IC50 of 8.4 nM.

Citation

Yoichi Hayakawa, Tomohiro Yoshida, Shoko Kimata, Kazuo Shin-Ya. Dunaimycin C3, a new GRP78 downregulator from Streptomyces sp. RAN389. The Journal of antibiotics. 2021 Jan;74(1):76-79