Correlation Engine 2.0
Clear Search sequence regions

  • human (2)
  • open (4)
  • orfs (3)
  • peptides (1)
  • rna (2)
  • zebrafish (2)
  • Sizes of these terms reflect their relevance to your search.

    Eukaryotic mRNAs were long thought to only translate a single protein product, but it is now recognized that many mRNAs can also encode small open reading frames (ORFs). In this issue of The EMBO Journal, Wu et al characterized small ORFs in the 3' untranslated regions (3' UTRs) of human and zebrafish mRNAs and found that many are indeed translated. The peptides encoded by these downstream ORFs (dORFs) are often poorly conserved across evolution, but many dORFs are nonetheless functional, as the act of their translation can promote translation of the canonical ORF. © 2020 The Authors.


    Samantha Dodbele, Jeremy E Wilusz. Ending on a high note: Downstream ORFs enhance mRNA translational output. The EMBO journal. 2020 Sep 01;39(17):e105959

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 32744723

    View Full Text