Non-Melanoma Skin Cancers: Biological and Clinical Features.

Non-melanoma skin cancers (NMSCs) include basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and Merkel cell carcinoma (MCC). These neoplasms are highly diverse in their clinical presentation, as well as in their biological evolution. While the deregulation of the Hedgehog pathway is commonly observed in BCC, SCC and MCC are characterized by a strikingly elevated mutational and neoantigen burden. As result of our improved understanding of the biology of non-melanoma skin cancers, innovative treatment options including inhibitors of the Hedgehog pathway and immunotherapeutic agents have been recently investigated against these malignancies, leading to their approval by regulatory authorities. Herein, we review the most relevant biological and clinical features of NMSC, focusing on innovative treatment approaches.

Citation

Mauro Cives, Francesco Mannavola, Lucia Lospalluti, Maria Chiara Sergi, Gerardo Cazzato, Elisabetta Filoni, Federica Cavallo, Giuseppe Giudice, Luigia Stefania Stucci, Camillo Porta, Marco Tucci. Non-Melanoma Skin Cancers: Biological and Clinical Features. International journal of molecular sciences. 2020 Jul 29;21(15)

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PMID: 32751327

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