The Link between Stress and IL-6 Is Heating Up.

Justin Darcy, Yu-Hua Tseng

Cell metabolism 2020 Aug 04

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Psychological stress has long been known to reduce adaptability to inflammatory challenges, although the precise mechanism has remained elusive. In a recent issue of Cell, Qing et al. (2020) demonstrate that psychological stress induces secretion of IL-6 from brown adipose tissue, which promotes hepatic gluconeogenesis, and reduces host fitness to inflammatory insults. Copyright © 2020 Elsevier Inc. All rights reserved.