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We present novel data concerning the time-course of adaptations and potential benefits of heat acclimation for people with cystic fibrosis (pwCF), who are at greater risk of exertional heat illness. A 25-year-old male (genotype: delta-F508 and RH117, forced expiratory volume in 1-second: 77% predicted and baseline sweat [Na+]: 70 mmol·L - 1), who had previously experienced muscle cramping during exercise in ambient heat, underwent 10-sessions of heat acclimation (90-min at 40°C and in 40% relative humidity). Adaptations included; lower resting core temperature (-0.40°C) and heart rate (-6 beats·min-1), plasma volume expansion (+6.0%) and, importantly, increased sweat loss (+370 mL) and sweat gland activity (+12 glands·cm2) with decreased sweat [Na+] (-18 mmol·L - 1). Adaptations were maintained for at least 7-days, with no evidence of cramping during follow-up exercise-heat stress testing. These data suggest pwCF may benefit from heat acclimation to induce sudomotor function improvements, particularly reductions in sweat [Na+], however, further research is required. Copyright © 2020. Published by Elsevier B.V.


Ashley G B Willmott, Robert Holliss, Zoe Saynor, Jo Corbett, Adam J Causer, Neil S Maxwell. Heat acclimation improves sweat gland function and lowers sweat sodium concentration in an adult with cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2021 May;20(3):485-488

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PMID: 32758394

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