Minutes of PPAR-γ agonism and neuroprotection.

Neurochemistry international 2020 Nov

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Peroxisome proliferator-activated receptor gamma (PPAR-γ) is one of the ligand-activated transcription factors which regulates a number of central events and considered as a promising target for various neurodegenerative disease conditions. Numerous reports implicate that PPAR-γ agonists have shown neuroprotective effects by regulating genes transcription associated with the pathogenesis of neurodegeneration. In regards, this review critically appraises the recent knowledge of PPAR-γ receptors in neuroprotection in order to hypothesize potential neuroprotective mechanism of PPAR-γ agonism in chronic neurological conditions. Of note, the PPAR-γ's interaction dynamics with PPAR-γ coactivator-1α (PGC-1α) has gained significant attention for neuroprotection. Likewise, a plethora of studies suggest that the PPAR-γ pathway can be actuated by the endogenous ligands present in the CNS and thus identification and development of novel agonist for the PPAR-γ receptor holds a vow to prevent neurodegeneration. Together, the critical insights of this review enlighten the translational possibilities of developing novel neuroprotective therapeutics targeting PPAR-γ for various neurodegenerative disease conditions. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

B R Prashantha Kumar, Ashwini Prem Kumar, Jincy A Jose, P Prabitha, S Yuvaraj, Sandhya Chipurupalli, Victoria Jeyarani, Chennu Manisha, Sayani Banerjee, Jeyaram Bharathi Jeyabalan, Suresh Kumar Mohankumar, S P Dhanabal, Antony Justin. Minutes of PPAR-γ agonism and neuroprotection. Neurochemistry international. 2020 Nov;140:104814