Triterpenoids and lignans from Schisandra chinensis and their inhibition activities of Cdc25A/B phosphatases.

Qian-Qian Zhao, Wen-Jun Wei, Ya Li, Kun Gao

Natural product research 2022 Feb

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Three new highly modified lanostane triterpenoids schisanchinlactone A-C (1-3), together with six known compounds (4-9) were isolated from the stems and leaves of Schisandra chinensis. Their structures were established by extensive spectroscopic analyses. Compounds 7 and 8 showed significant inhibition of Cdc25A phosphatase with inhibitory rates of 85.5% and 98.1%, respectively, at the concentration of 100 μM.

Citation

Qian-Qian Zhao, Wen-Jun Wei, Ya Li, Kun Gao. Triterpenoids and lignans from Schisandra chinensis and their inhibition activities of Cdc25A/B phosphatases. Natural product research. 2022 Feb;36(3):754-759