Roles of Annexin A protein family in autophagy regulation and therapy.

Yufeng Xi, Rong Ju, Yujia Wang

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct

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Annexin A is a kind of calcium-dependent phospholipid-binding proteins, which contributes to the formation of the cell membranes and cytoskeleton and played a part as a membrane skeleton to stabilize lipid bilayer. Autophagy is one of the most important programmed cell death mechanisms. And recently some reports suggest that annexin A family protein is associated with autophagy for annexin A can regulate the formation of vesicular lipid membranes and promote cell exocytosis. In this review, we summarized the roles of annexin A protein family in autophagy regulation and targeted medical treatment for better diagnoses and therapies. Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.

Citation

Yufeng Xi, Rong Ju, Yujia Wang. Roles of Annexin A protein family in autophagy regulation and therapy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Oct;130:110591