Niloofarsadat Maddahi, Habib Yarizadeh, Seyed Mohammad Kazem Aghamir, Shahab Alizadeh, Mir Saeed Yekaninejad, Khadijeh Mirzaei
BMC research notes 2020 Aug 08Inflammation plays a leading role in the pathogenesis of nephrolithiasis. The association of the dietary inflammatory index (DII) with urinary lithogenic factors is unclear. This study aimed to evaluate the relation of DII to urinary risk factors of kidney stones formation. Of 264 participants, 61.4% (n = 162), 72% (n = 190), 74.6% (n = 197), 68.6% (n = 181), and 80.3% (n = 212) had hyperoxaluria, hypercreatininuria, hypercalciuria, hyperuricosuria, hypocitraturia, respectively. There was a significant increasing trajectory in urinary calcium, uric acid, and creatinine as well as a decreasing trend in urinary citrate across tertiles of DII score (all P = ≤0.001). After multivariate adjustment for energy intake, age, physical activity and body mass index, high DII scores were associated with elevated odds of having hypercreatininuria (OR = 2.80, 95%CI: 1.10-7.12, Ptrend = 0.04), hypercalciuria (OR = 7.44, 95%CI: 2.62-21.14, Ptrend ≤ 0.001), hyperuricosuria (OR = 2.22, 95%CI: 1.001-4.95, Ptrend = 0.05), and hypocitraturia (OR = 5.84, 95%CI: 2.14-15.91, Ptrend ≤ 0.001). No association was identified between DII and hyperoxaluria.
Niloofarsadat Maddahi, Habib Yarizadeh, Seyed Mohammad Kazem Aghamir, Shahab Alizadeh, Mir Saeed Yekaninejad, Khadijeh Mirzaei. The association of dietary inflammatory index with urinary risk factors of kidney stones formation in men with nephrolithiasis. BMC research notes. 2020 Aug 08;13(1):373
PMID: 32771046
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