The RNA-Binding Protein HuR in Digestive System Tumors.

Xiaoqing Song, Xin Shi, Wenjuan Li, Fa Zhang, Zhonglin Cai

BioMed research international 2020

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Human antigen R (HuR) is a member of the Hu family of RNA-binding proteins. This molecule, which was first described in tumors nearly two decades ago, has recently received much attention in tumor-related research because it regulates the expression of many tumor-associated molecules through posttranscriptional regulatory mechanisms, thereby affecting biological characteristics. It is suggested that HuR might be a novel therapeutic target and a marker for therapeutic response and prognostic assessment. Increasing evidence supports that HuR also plays critical roles in the development, therapy, and prognosis of digestive system tumors. Herein, we review the relationships between HuR and digestive system tumors, demonstrating the importance of HuR in digestive system tumor diagnosis. Copyright © 2020 Xiaoqing Song et al.

Citation

Xiaoqing Song, Xin Shi, Wenjuan Li, Fa Zhang, Zhonglin Cai. The RNA-Binding Protein HuR in Digestive System Tumors. BioMed research international. 2020;2020:9656051