Solidagenone from Solidago chilensis Meyen inhibits skin inflammation in experimental models.

Simone S Valverde, Bruna Celeida S Santos, Temístocles B de Oliveira, Guilherme C Gonçalves, Orlando V de Sousa

Basic & clinical pharmacology & toxicology 2021 Jan

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Solidagenone (SOL) is a labdane-type diterpenoid found in Solidago chilensis, a plant traditionally used to treat skin diseases, kidney pain and ovarian inflammation. In this study, the topical anti-inflammatory activity of SOL was evaluated using in vivo and in silico assays. Croton oil-, arachidonic acid (AA)- and phenol-induced ear oedema mouse models were applied in the in vivo studies. Myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAG) activities and tumour necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and nitric oxide (NO) levels were determined, as well as histopathological analyses were conducted. Interaction profiles between SOL and cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), glucocorticoid receptor, estradiol-17-β-dehydrogenase and prostaglandin-E(2)-9-reductase were established using molecular docking. SOL significantly inhibited croton oil-, AA- and phenol-induced ear oedema (P < .001) at doses of 0.1, 0.5 and 1.0 mg/ear. The MPO and NAG activities and TNF-α, IL-6 and NO levels were decreased (P < .001). The histopathological data revealed that inflammatory parameters (oedema thickness, leucocyte infiltration and vasodilatation) were reduced by treatment with SOL at doses of 0.1, 0.5 and 1.0 mg/ear. The docking study showed that SOL interacts with COX-1 and prostaglandin-E(2)-9-reductase through hydrogen bonding, inhibiting these enzymes. These results indicate that SOL may be a promising compound for the treatment of cutaneous inflammatory disorders and has potential as a topical anti-inflammatory agent. © 2020 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).

Citation

Simone S Valverde, Bruna Celeida S Santos, Temístocles B de Oliveira, Guilherme C Gonçalves, Orlando V de Sousa. Solidagenone from Solidago chilensis Meyen inhibits skin inflammation in experimental models. Basic & clinical pharmacology & toxicology. 2021 Jan;128(1):91-102