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The plant species Anemarrhena asphodeloides has commonly been used for health and therapeutic purposes. Timosaponin B-II, which is present at a high concentration in A asphodeloides, was found to enhance the immune and anti-inflammatory responses of human bodies. To evaluate benefits of a timosaponin B-II containing scalp care solution on hair loss prevention and scalp healthiness in multiple physiological and biological profiles. Prior the study, 90 subjects applied scalp care solution base without timosaponin B-II for two weeks followed by application of the scalp care solution containing 0.5% timosaponin B-II for 28 days. The subject's hair follicle hydrocortisone level, hair fall number, hair luster level, dandruff level, sensation score, hydration level, lipid level, redness as well as the pH level of scalps were quantitatively assessed every 7 days. Multiple parameters on hair and scalp conditions were promoted by application of the timosaponin B-II containing scalp care solution. Compared to baseline values, significant improvements in hair luster, scalp hydration, hair fall number, and scalp redness level could be observed. Timosaponin B-II promotes multiple physiological factors on hair and scalps. The scalp care solution containing A asphodeloides extracts may benefit the scalp healthiness and hair loss prevention. © 2020 Wiley Periodicals LLC.


Lei Xiao, Xia Zhang, Zhiyi Chen, Bing Li, Lin Li. A Timosaponin B-II containing scalp care solution for improvement of scalp hydration, dandruff reduction, and hair loss prevention: A comparative study on healthy volunteers before and after application. Journal of cosmetic dermatology. 2021 Mar;20(3):819-824

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PMID: 32780920

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