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A 68-year-old man visited our hospital due to anorexia, weight loss and a fever. We diagnosed the patient with disseminated Mycobacterium avium complex (MAC) and confirmed the presence of interferon (IFN)-γ neutralizing autoantibodies (IFN-γAb). His lesions improved following antibiotic therapy, but chylous ascites (CA) developed seven months after treatment. CA was able to be controlled by subcutaneous octreotide and diet therapy. IFN-γAb is recognized as having a critical role in the pathogenesis of disseminated MAC disease, but its clinical features are not fully understood. CA may be a complication that develops during the treatment of disseminated MAC infection.


Yusuke Yamaba, Osamu Takakuwa, Ziren Wang, Manami Saito, Daisuke Kawae, Misuzu Yoshihara, Eiji Kunii, Yutaka Ito, Kenji Akita. Disseminated Mycobacterium avium Infection Complicated with Chylous Ascites in a Patient with Neutralizing Autoantibodies to Interferon-γ. Internal medicine (Tokyo, Japan). 2020 Dec 15;59(24):3195-3200

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PMID: 32788530

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