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    The goal of this study was to find the optimal combination of collimator, photopeak and scatter correction for 177 Lutetium (177 Lu) SPECT/CT imaging. Three experiments [sphere-to-background ratios (SBR) 50:1, 10:1, and 2:1] were performed with the NEMA Image Quality phantom filled with 177 Lu-trichloride. SPECT/CT acquisitions were performed with the medium-energy low-penetration (MELP) collimator and 99m Tc/Krypton collimator. For each acquisition six reconstructions, all with attenuation correction (AC), were made: the 113-keV photopeak only, the 208-keV photopeak only and both photopeaks combined, each with or without scatter correction (SC). Image quality was assessed using contrast-to-noise ratios (CNR), quantification accuracy by means of recovery coefficients (RCs) and the spatial resolution using line profiles. With SBR 50:1 and 10:1, both collimators met the Rose criterion (CNR > 5), whereas the MELP collimator showed a higher CNR for the 2:1 ratio. The RCmean was higher with the MELP collimator, most explicit after the 208-keV AC/SC reconstruction for all acquisitions. The line profiles showed a better spatial resolution for the MELP collimator and the 208-keV AC/SC reconstructions. 177 Lu SPECT/CT image quality and quantification was most optimal when acquired with the MELP collimator and reconstructed using the 208-keV photopeak, with AC and SC. © 2020 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.


    Daphne M V Huizing, Michiel Sinaasappel, Marien C Dekker, Marcel P M Stokkel, Berlinda J de Wit-van der Veen. 177 Lutetium SPECT/CT: Evaluation of collimator, photopeak and scatter correction. Journal of applied clinical medical physics. 2020 Sep;21(9):272-277

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    PMID: 32790140

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