Lack of association between CYP11B2 -344T/C polymorphism and transient ischemic attack in a Chinese population.

This study investigated whether the CYP11B2 -344T/C polymorphism is correlated with transient ischemic attack (TIA) susceptibility. We recruited 100 TIA patients and 100 control subjects and analyzed the CYP11B2 -344T/C polymorphism using restriction fragment length polymorphism (PCR-RFLP). The frequency in TIA patients and controls was 42% compared with 48% for TT genotypes, 51% compared with 45% for TC genotypes, and 7% compared with 7% for CC genotype, respectively. Allele frequencies in TIA patients and controls were 67.5% compared with 70.5% for T-allele and 32.5% compared with 29.5% for C-allele, respectively. No association between the CYP11B2 -344T/C polymorphism and TIA was observed in all comparisons. Our data suggest that there was no association between the CYP11B2 -344T/C polymorphism and TIA in a Chinese population.

Citation

Jia Fan, Yaoliang Shen, Bo Chen, Chunyang Xu, Hongwei Ye, Jian Wang, Wenjun Zhou, Yuefeng Sheng, Feng Xu, Peng Yang. Lack of association between CYP11B2 -344T/C polymorphism and transient ischemic attack in a Chinese population. The Journal of international medical research. 2020 Aug;48(8):300060520947916

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PMID: 32790508

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