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Protecting-group-free synthesis of hydroxyesters from amino alcohols.
Chemical communications (Cambridge, England) 2020 Sep 21Sizes of these terms reflect their relevance to your search.
The synthesis of hydroxyesters from carboxylic acids and unprotected amino alcohols in both continuous flow and batch processes is reported. The formation of a transient diazonium species with a dinitrite reagent is key in this transformation. The reaction conditions are compatible with a variety of functional groups.
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Guillaume Reynard, Eve-Marline Joseph-Valcin, Hélène Lebel. Protecting-group-free synthesis of hydroxyesters from amino alcohols. Chemical communications (Cambridge, England). 2020 Sep 21;56(74):10938-10941
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PMID: 32797120
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