Meta-analysis of the Effect of Treatment Strategies for Nephrosplenic Entrapment of the Large Colon.

Alex Gillen, Jack Kottwitz, Amelia Munsterman

Journal of equine veterinary science 2020 Sep

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A variety of treatment strategies for nephrosplenic entrapment of the large colon are reported, with conflicting evidence in the published literature as to the preferred treatment option. The aim of this study is to provide a systematic meta-analytical assessment of the efficacy of different treatment strategies in horses with confirmed or suspected nephrosplenic entrapment. This study involves meta-analysis including nonrandomized studies. A comprehensive literature search was performed from January 1970 to January 2017. Inclusion criteria were retrospective studies involving horses with confirmed and suspected nephrosplenic entrapment. A meta-analysis was performed using a random effects model, with the effect size calculated as an odds ratio (OR) with 95% confidence intervals. Statistical significance was P < .05. Out of 84 peer reviewed publications that met the search criteria, 19 relevant studies were identified. Using an OR as the effect size, the meta-analysis noted that the choice of medical or surgical therapy had no statistically significant effect on survival (P = .134). Patients treated via the rolling technique were no more likely to resolve with medical management than those treated via jogging (P = .187). Patients treated with phenylephrine were no more likely to exhibit medical resolution than patients that did not receive phenylephrine, either when all medical treatment methods were considered (P = .290), or when rolling under general anesthesia was used (P = .331). Treatment strategy, including medical versus surgical therapy, does not affect the likelihood of resolution of nephrosplenic entrapment. However, the lack of randomized trials means the results should be treated with caution and case selection remains important.. Crown Copyright © 2020. Published by Elsevier Inc. All rights reserved.

Citation

Alex Gillen, Jack Kottwitz, Amelia Munsterman. Meta-analysis of the Effect of Treatment Strategies for Nephrosplenic Entrapment of the Large Colon. Journal of equine veterinary science. 2020 Sep;92:103169