Glycyl-l-glutamine attenuates NPY-induced hyperphagia via the melanocortin system.

Jun-Ichi Shiraishi, Kouichi Yanagita, Hiroshi Tanizawa, Takashi Bungo

Neuroscience letters 2020 Sep 25

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This study aimed to determine whether glycyl-l-glutamine (Gly-Gln; β-endorphin (30-31)), a non-opioid peptide derived from β-endorphin processing, modulates neuropeptide Y (NPY)-induced feeding and hypothalamic mRNA expression of peptide hormones in male broiler chicks. Intracerebroventricular injection of NPY (235 pmol) generated a hyperphagic response in ad libitum chicks within 30 min. Co-administration of Gly-Gln (100 nmol) attenuated this response, inducing a 30 % decrease. This was not attributable to Gly-Gln hydrolysis because co-administration of glycine (Gly) and glutamine (Gln) had no effect on NPY-induced hyperphagia. Gly-Gln injected alone also showed no effect. The hypothalamic pro-opiomelanocortin mRNA expression in the co-injection group was significantly higher than that in the NPY alone group. These data indicate that endogenous Gly-Gln may contribute to regulate feeding behavior via the central melanocortin system in chicks and acts as a counter regulator of the neural activity in energy metabolism. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Jun-Ichi Shiraishi, Kouichi Yanagita, Hiroshi Tanizawa, Takashi Bungo. Glycyl-l-glutamine attenuates NPY-induced hyperphagia via the melanocortin system. Neuroscience letters. 2020 Sep 25;736:135303