Determining the site of cell cleavage is crucial for cytokinesis and involves precise activation of the RhoGEF ECT2. A new study demonstrates how a non-canonical interaction of ECT2 with centralspindlin underlies cytokinesis in animal cells, solving a mechanistic conundrum. Copyright © 2020 Elsevier Inc. All rights reserved.
Mark Petronczki, Antonio Tedeschi. Cell Division: Switching On ECT2 in a Non-Canonical Fashion. Current biology : CB. 2020 Aug 17;30(16):R947-R949
PMID: 32810457
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