Ten New Dammarane-Type Saponins with Hypolipidemia Activity from a Functional Herbal Tea-Gynostemma pentaphyllum.

Maojing Yin, Jingjing Zhang, Lizhi Wang, Fangyi Li, Zhenfa Li, Wei Xiang, Songtao Bie, Chunhua Wang, Zheng Li

Molecules (Basel, Switzerland) 2020 Aug 15

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Gynostemma pentaphyllum (thumb.) Makino is a functional herbal tea commonly used in Asian countries and regions to reduce blood lipid levels. G. pentaphyllum saponin is the main component, but there are still a large number of components with lipid-lowering activity that have not been found. In this study, 10 novel dammarane-type saponins, (1-10) and a known one (11) were isolated from G. pentaphyllum. Ten new compounds were identified and named as yunnangypenosides A-J (1-10), and another known one (11) was also obtained. Their chemical structures were determined by MS, NMR spectroscopic analyses. Moreover, the cytotoxicities on human HepG-2 hepatocellular carcinoma cells of these isolates were evaluated, and the results showed that compounds 1-11 had no obvious cytotoxicity. Finally, all these compounds were evaluated for their lipid-lowering effect by means of the oil red O staining method. Ten compounds could significantly reduce lipid levels except of 2, especially 8 exhibite the strongest hypolipidemia activity.

Citation

Maojing Yin, Jingjing Zhang, Lizhi Wang, Fangyi Li, Zhenfa Li, Wei Xiang, Songtao Bie, Chunhua Wang, Zheng Li. Ten New Dammarane-Type Saponins with Hypolipidemia Activity from a Functional Herbal Tea-Gynostemma pentaphyllum. Molecules (Basel, Switzerland). 2020 Aug 15;25(16)