Acylated Flavone O-Glucuronides from the Aerial Parts of Nepeta curviflora.

Maysaa Rabee, Øyvind Moksheim Andersen, Torgils Fossen, Kjersti Hasle Enerstvedt, Hijazi Abu Ali, Saleh Rayyan

Molecules (Basel, Switzerland) 2020 Aug 20

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Nepeta curviflora Boiss. (Syrian catnip) is native to the Middle East. This medicinal plant is commonly used against nervous disorders, rheumatic pains, and high blood pressure. Herbal infusions prepared from various Nepeta spp. are extensively consumed as functional food. However, limited information has been known about the phenolic constituents of Syrian catnip. In this study, two acylated flavone 7-O-glucuronides, apigenin 7-O-(2″-O-(2‴-(E-caffeoyl)-β-glucuronopyranosyl)-β-glucuronopyranoside) (1) and luteolin 7-O-(2″-O-(2‴-(E-caffeoyl)-β-glucuronopyranosyl)-β-glucuronopyranoside) (2), along with the known phenolic compounds rosmarinic acid, caffeic acid, apigenin, and apigenin 7-O-β-glucopyranoside were isolated from the aerial parts of N. curviflora. The characterizations of these compounds were based on high-resolution mass spectrometry, UV, and extensive use of multidimensional NMR spectroscopy. The new compounds (1 and 2) were identified in the unmodified state and as dimethylesters.

Citation

Maysaa Rabee, Øyvind Moksheim Andersen, Torgils Fossen, Kjersti Hasle Enerstvedt, Hijazi Abu Ali, Saleh Rayyan. Acylated Flavone O-Glucuronides from the Aerial Parts of Nepeta curviflora. Molecules (Basel, Switzerland). 2020 Aug 20;25(17)