High SYT7 expression is associated with poor prognosis in human non-small cell lung carcinoma.

Qiuyue Han, Dan Zou, Fei Lv, Song Wang, Chunjiao Yang, Jincheng Song, Zhenpeng Wen, Ye Zhang

Pathology, research and practice 2020 Sep

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Synaptotagmin 7 (SYT7) can encode a single-pass 46-kDa transmembrane protein which located on human chromosome 11q12.2. It has been reported to be dysregulated in several cancers; however, there are few reports on the role of SYT7 in non-small cell lung carcinoma (NSCLC). The purpose of our study was to investigate the expression of SYT7 in NSCLC and its relationship with the prognosis of NSCLC. Differences in SYT7 expression were explored by using a public database and tissue samples. The prognostic value of SYT7 and its expression correlation with clinical parameters were evaluated by statistical analysis. Our current study found that elevated mRNA and protein levels of SYT7 in NSCLC tissues compared to adjacent normal tissues. The high expression of SYT7 in NSCLC patients was positively correlated with tumour differentiation (P = 0.031) and pT (P = 0.041). The higher SYT7 expression had a shorter survival time than those with lower SYT7 expression in NSCLC patients. Furthermore, multivariate analysis demonstrated that the expression of SYT7 was an unfavourable independent prognostic factor for NSCLC (P = 0.044). In conclusion, SYT7 was upregulated in NSCLC tissues and maybe a prognostic and diagnostic factor of NSCLC. Copyright © 2020 Elsevier GmbH. All rights reserved.

Citation

Qiuyue Han, Dan Zou, Fei Lv, Song Wang, Chunjiao Yang, Jincheng Song, Zhenpeng Wen, Ye Zhang. High SYT7 expression is associated with poor prognosis in human non-small cell lung carcinoma. Pathology, research and practice. 2020 Sep;216(9):153101