Correlation Engine 2.0
Clear Search sequence regions

  • alphavirus (8)
  • gene (4)
  • humans (1)
  • mice (1)
  • plasmid (6)
  • replicon (1)
  • rna (1)
  • rodents (1)
  • swine (1)
  • vaccines dna (3)
  • Sizes of these terms reflect their relevance to your search.

    Alphavirus vectors have been engineered for high-level gene expression relying originally on replication-deficient recombinant particles, more recently designed for plasmid DNA-based administration. As alphavirus-based DNA vectors encode the alphavirus RNA replicon genes, enhanced transgene expression in comparison to conventional DNA plasmids is achieved. Immunization studies with alphavirus-based DNA plasmids have elicited specific antibody production, have generated tumor regression and protection against challenges with infectious agents and tumor cells in various animal models. A limited number of clinical trials have been conducted with alphavirus DNA vectors. Compared to conventional plasmid DNA-based immunization, alphavirus DNA vectors required 1000-fold less DNA to elicit similar immune responses in rodents.


    Kenneth Lundstrom. Impact of a Plasmid DNA-Based Alphavirus Vaccine on Immunization Efficiency. Methods in molecular biology (Clifton, N.J.). 2021;2197:33-47

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 32827131

    View Full Text