Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus.

Marco Fuenzalida, Chiayu Q Chiu, Andrés E Chávez

Neuroscience 2021 Feb 21

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Long-term changes in synaptic transmission between neurons in the brain are considered the cellular basis of learning and memory. Over the last few decades, many studies have revealed that the precise order and timing of activity between pre- and post-synaptic cells ("spike-timing-dependent plasticity; STDP") is crucial for the sign and magnitude of long-term changes at many central synapses. Acetylcholine (ACh) via the recruitment of diverse muscarinic receptors is known to influence STDP in a variety of ways, enabling flexibility and adaptability in brain network activity during complex behaviors. In this review, we will summarize and discuss different mechanistic aspects of muscarinic modulation of timing-dependent plasticity at both excitatory and inhibitory synapses in the hippocampus to shape learning and memory. Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

Citation

Marco Fuenzalida, Chiayu Q Chiu, Andrés E Chávez. Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus. Neuroscience. 2021 Feb 21;456:50-59