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An 80-year-old woman presented with a 30-mm protruding lesion-like submucosal tumor with a central depression located at the anterior wall of the upper gastric body. The depressed area had a well-demarcated margin, while the other area was covered by a non-neoplastic mucosa. A biopsy specimen revealed neuroendocrine carcinoma. Endoscopic ultrasonography revealed a heterogeneous mass with a clearly distinguished border in the submucosal layer. The mass had two distinct areas adjacent to each other. In addition, a hypoechoic zone was observed on the margin of the mass. Distal gastrectomy was performed. The final diagnosis was a mixed neuroendocrine-non-neuroendocrine neoplasm arising from the heterotopic gastric gland.

Citation

Yasuyuki Tanaka, Yumi Tokubayashi, Shigehiko Fujii, Toshihiro Kusaka, Shinsuke Shibuya, Hiroyuki Kokuryu. Gastric MiNEN Arising from the Heterotopic Gastric Glands. Internal medicine (Tokyo, Japan). 2020 Dec 15;59(24):3165-3169

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PMID: 32830181

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