Total Synthesis of Glycosylated Human Interferon-γ.

Xiaoyi Wang, Anneliese S Ashhurst, Luke J Dowman, Emma E Watson, Henry Y Li, Antony J Fairbanks, Mark Larance, Ann Kwan, Richard J Payne

Organic letters 2020 Sep 04

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Interferon-γ (IFN-γ) is a glycoprotein that is responsible for orchestrating numerous critical immune induction and modulation processes and is used clinically for the treatment of a number of diseases. Herein, we describe the total chemical synthesis of homogeneously glycosylated variants of human IFN-γ using a tandem diselenide-selenoester ligation-deselenization strategy in the C- to N-terminal direction. The synthetic glycoproteins were successfully folded, and the structures and antiviral functions were assessed.

Citation

Xiaoyi Wang, Anneliese S Ashhurst, Luke J Dowman, Emma E Watson, Henry Y Li, Antony J Fairbanks, Mark Larance, Ann Kwan, Richard J Payne. Total Synthesis of Glycosylated Human Interferon-γ. Organic letters. 2020 Sep 04;22(17):6863-6867