Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Myeloid malignancies are associated with a number of recurrent and sporadic rearrangements that may be oncogenic by ensuring growth advantage and/or increased survival. t(3;3)(q21;q26) has been recognized as a recurrent abnormality in myelodysplastic syndromes (MDS) with poor prognostic significance. Inversion of chr(11) engendering NUP98-DDX10 chimeric product is sporadic and usually associated with diseases with poor prognosis (therapy-related myeloid neoplasm). To date, these cytogenetic abnormalities have been described as isolated events. We report the first case of an 80-year-old man with high-risk MDS harboring a translocation t(3,3)(q21q26) jointly with an inv(11)(p15q22) detected by fluorescent in situ hybridization analysis and conventional cytogenetic techniques. A similar pattern of acquisition was never described before in MDS. The coexistence of two independent, high-risk oncogenic, rare events in the same clone suggests that there may be a functional constraint for synergy between the two events, leading to a proliferative advantage and suggests the utility of extended genotyping in myeloid malignancies.


Valentina Monti, Filippo Bagnoli, Niccolo' Bolli, Laura Vittoria, Sabine Stioui, Maria Luisa Moiraghi, Giancarlo Pruneri, Maria Adele Testi. A new case of myelodysplastic syndrome associated with t(3;3)(q21;q26) and inv(11)(p15q22). Tumori. 2020 Dec;106(6):NP18-NP22

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 32831008

View Full Text