The genome of influenza A virus (IAV) comprises eight segmented, single-stranded, negative-sense RNAs. The genome packaging mechanism of IAV was a long-standing enigma, but it is now widely accepted that IAV packages one copy of each of the eight viral RNA (vRNA) segments in a selective manner. Accumulating evidence over the last decade suggests that the eight unique vRNAs are selected via intersegment interactions mediated by their segment-specific genome packaging signals; however, the characteristics of these RNA-based interactions largely remain unknown. This review summarizes our current knowledge of IAV selective genome packaging and the possible mechanisms underlying the selection of the eight unique vRNAs. Copyright © 2021 Cold Spring Harbor Laboratory Press; all rights reserved.
Takeshi Noda. Selective Genome Packaging Mechanisms of Influenza A Viruses. Cold Spring Harbor perspectives in medicine. 2021 Jul 01;11(7)
PMID: 32839251
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