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Certain medications have been implicated in causing acute myocardial infarctions (AMI). Sumatriptan, a medication usually prescribed for acute migraine and cluster headaches has been documented as potentially causing coronary vasospasm, thereby leading to MI. This is usually seen in patients with strong risk factors for coronary artery disease (CAD) or in those with established CAD. Most cases thus far have been reported in patients using the subcutaneous preparation of sumatriptan. Here, we present a case of a patient without prior risk factors for CAD and angiographically unremarkable coronary arteries who presented with evidence of an AMI after oral sumatriptan use for migraines. © BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.


Kenneth Okonkwo, Utkarsh Ojha. Vasospasm induced myocardial ischaemia secondary to sumatriptan use. BMJ case reports. 2020 Aug 24;13(8)

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PMID: 32843411

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