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Phytochemical investigation of the roots of Rothmannia wittii led to the isolation of three new iridoid glucosides, named rothmanniosides A-C (1-3), and nine known compounds (4-12). Their structures, including their absolute configurations, were elucidated by thorough analysis of mass spectrometric and NMR spectroscopic data, together with CD calculations. Compounds 4 and 11 are reported from the Rubiaceae family for the first time.


Awat Wisetsai, Florian T Schevenels, Kiatichai Faksri, Sarawut Tontapha, Vittaya Amornkitbamrung, Ratsami Lekphrom. New iridoid glucosides from the roots of Rothmannia wittii (Craib) Bremek. Natural product research. 2022 Apr;36(7):1716-1724

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PMID: 32851863

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