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CHI3L1 in the pathophysiology and diagnosis of liver diseases.

Shuwei Wang, Mengyuan Hu, Yunsong Qian, Zhenluo Jiang, Lili Shen, Liyun Fu, Yaoren Hu

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov


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    Chitinase 3-like protein 1(CHI3L1) participates in physiological and pathophysiological process, such as cell survival, cell proliferation, tissue remodeling, angiogenesis, etc. Some studies demonstrated that CHI3L1 is liver-enriched and has better application value in staging liver fibrosis than platelet ratio index(APRI) and fibrosis-4 index(FIB-4) and that CHI3L1 can be used in monitoring the prognosis of hepatocellular carcinoma (HCC). In this review, we summarized the pathophysiological role and the diagnostic value of CHI3L1 in liver fibrosis in different background and HCC. Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

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    Shuwei Wang, Mengyuan Hu, Yunsong Qian, Zhenluo Jiang, Lili Shen, Liyun Fu, Yaoren Hu. CHI3L1 in the pathophysiology and diagnosis of liver diseases. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Nov;131:110680

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    PMID: 32861071

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