Antiviral activity of green silver nanoparticles produced using aqueous buds extract of Syzygium aromaticum.

Yasir Mehmood, Umar Farooq, Hammad Yousaf, Humayun Riaz, Rana Khalid Mahmood, Ahmad Nawaz, Zoya Abid, Mahpara Gondal, Nadia Shamshad Malik, Kashif Barkat, Ikrima Khalid

Pakistan journal of pharmaceutical sciences 2020 Mar

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In the present study, we synthesized silver (Ag) nanoparticles using aqueous extracts of clove (Syzygium aromaticum) (SAE). This synthesis of green silver nanoparticles (AgNP) was a novel and effectual tool against the Newcastle Viral Disease (NDV). Syzygium aromaticum extract was used as reducing and stabilizing agent for synthesis of silver nanoparticles. AgNP were characterized using diversity of biophysical methods inclusive of Fourier transform infrared spectroscopy (FTIR), UV-VIS spectroscopy and Transmission electron microscopy (TEM) for morphology and size. Furthermore, XRD analysis confirmed the crystalline nature of the particles. In current investigations, the antiviral activity of clove buds silver nanoparticles was inspected in-vitro and in-ovo. Embryonated chicken eggs were used to perform the cytotoxicity assay of the clove extract silver nanoparticles (CESN). CESN showed in vitro antiviral activity against NDV in embryonated eggs.

Citation

Yasir Mehmood, Umar Farooq, Hammad Yousaf, Humayun Riaz, Rana Khalid Mahmood, Ahmad Nawaz, Zoya Abid, Mahpara Gondal, Nadia Shamshad Malik, Kashif Barkat, Ikrima Khalid. Antiviral activity of green silver nanoparticles produced using aqueous buds extract of Syzygium aromaticum. Pakistan journal of pharmaceutical sciences. 2020 Mar;33(2(Supplementary)):839-845