Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Shigella, a major cause of bacterial dysentery, knows when it is not wanted. To generate and maintain its niche within host cells, this unwelcome guest injects several dozen virulence factors via a type 3 secretion system (T3SS). In this issue, Ashida et al (2020) have elucidated the role of two such factors from Shigella flexneri-OspC1 and OspD3-that together counteract apoptotic and necroptotic death pathways in colonised epithelial cells. As a result, Shigella can replicate to high levels within the colonic epithelium, leading to the substantial epithelial damage in shigellosis and efficient bacterial release for faecal transmission. © 2020 The Authors.


Sara J Thygesen, Adriana Pliego-Zamora, Katryn J Stacey. Manipulation of epithelial cell death pathways by Shigella. The EMBO journal. 2020 Sep 01;39(17):e106202

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 32869315

View Full Text