Timing Is Everything: Misincorporation of 8oxodG during Mitosis Is Lethal.

Khadijeh Alnajjar, Joann B Sweasy

Cancer research 2020 Sep 01

filter terms:

Exploiting universal cancer vulnerabilities has been used as an approach for developing targeted therapies. In this issue of Cancer Research, Rudd and colleagues show that the dual-functioning inhibitor TH588 potentiates the accumulation of reactive oxygen species during mitosis in cancer by disturbing mitotic progression and simultaneously inhibiting the hydrolysis of 8oxodGTP. This leads to increased incorporation of 8oxodG into the DNA during mitotic replication and increased toxicity. Understanding the mechanism of this inhibitor lays the groundwork for identifying cancer targets.See related article by Rudd et al., p. 3530. ©2020 American Association for Cancer Research.

Citation

Khadijeh Alnajjar, Joann B Sweasy. Timing Is Everything: Misincorporation of 8oxodG during Mitosis Is Lethal. Cancer research. 2020 Sep 01;80(17):3459-3460