Exploration of CTNNB1 ctDNA as a putative biomarker for hepatoblastoma.

Smadar Kahana-Edwin, Geoffrey McCowage, Lucy Cain, Federica Saletta, Aysen Yuksel, Nicole Graf, Jonathan Karpelowsky

Pediatric blood & cancer 2020 Nov

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Driver mutations in the CTNNB1 gene (encoding β-catenin) are a hallmark of sporadic hepatoblastoma (HBL). Our results show that CTNNB1 circulating tumour DNA (ctDNA) is readily detected in patients diagnosed with localised HBL, with serial sampling along the course of therapy and follow up providing a sensitive mechanism to monitor tumour dynamics and response to treatment. This exciting potential for CTNNB1 ctDNA to serve as a biomarker for treatment response in HBL holds clinical value, and requires assessment in a larger cohort of mixed tumour stages and recurrent disease. © 2020 Wiley Periodicals LLC.

Citation

Smadar Kahana-Edwin, Geoffrey McCowage, Lucy Cain, Federica Saletta, Aysen Yuksel, Nicole Graf, Jonathan Karpelowsky. Exploration of CTNNB1 ctDNA as a putative biomarker for hepatoblastoma. Pediatric blood & cancer. 2020 Nov;67(11):e28594