Correlation Engine 2.0
Clear Search sequence regions


  • adult (1)
  • born canada (2)
  • canada (3)
  • cohort (1)
  • contains (1)
  • direct (4)
  • female (1)
  • hepacivirus (1)
  • humans (1)
  • patients (3)
  • race (3)
  • treatment outcomes (2)
  • Sizes of these terms reflect their relevance to your search.

    There are multiple obstacles encountered by immigrants attempting to engage hepatitis C virus (HCV) care and treatment. We evaluated the diversity and treatment outcomes of HCV-infected immigrants evaluated for Direct Acting Antiviral (DAA) therapy in Canada. The Canadian Network Undertaking against Hepatitis C (CANUHC) Cohort contains demographic information and DAA treatment information prospectively collected at 10 Canadian sites. Information on country of origin and race are collected. Characteristics and outcomes (sustained virological response; SVR) were compared by immigration status and race. Between January 2016 and May 2018, 725 HCV-infected patients assessed for DAA therapy were enrolled in CANUHC (mean age: 52.66 ± 12.68 years); 65.66% male; 82.08% White, 5.28% Indigenous, 4.64% South East Asian, 4.64% East Indian, 3.36% Black). 18.48% were born outside of Canada. Mean age was similar [immigrants: 54.36 ± 13.95 years), Canadian-born: 52.27 ± 12.35 years); (p = 0.085)]. The overall baseline fibrosis score (in kPa measured by transient elastography) was similar among Canadian and foreign-born patients. Fibrosis score was not predicted by race or genotype. The proportion initiating DAA therapy was similar by immigrant status (56.72% vs 49.92%). SVR rates by intent-to-treat analysis were similar (immigrants-89.47%, Canadian-born-92.52%; p = 0.575). A diverse immigrant population is engaging care in Canada, initiating HCV antiviral therapy in an equitable fashion and achieving SVR proportions similar to Canada-born patients. Our Canadian experience may be of value in informing HCV elimination efforts in economically developed regions.

    Citation

    Curtis L Cooper, Daniel Read, Marie-Louise Vachon, Brian Conway, Alexander Wong, Alnoor Ramji, Sergio Borgia, Ed Tam, Lisa Barrett, Dan Smyth, Jordan J Feld, Sam Lee, CANUHC Cohort. Hepatitis C virus infection characteristics and treatment outcomes in Canadian immigrants. BMC public health. 2020 Sep 03;20(1):1345

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 32883249

    View Full Text