Gastric parietal cell and thyroid autoantibodies in patients with burning mouth syndrome.

Chun-Pin Chiang, Yang-Che Wu, Yu-Hsueh Wu, Julia Yu-Fong Chang, Yi-Ping Wang, Andy Sun

Journal of the Formosan Medical Association = Taiwan yi zhi 2020 Dec

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Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in burning mouth syndrome (BMS) patients. Serum GPCA, TGA, and TMA levels were measured in 884 BMS patients and in 442 age- and sex-matched healthy control subjects. We found that 12.3%, 21.6%, and 22.7% of 884 BMS patients and 1.8%, 2.3%, and 2.9% of 442 healthy control subjects had the serum GPCA, TGA, and TMA positivities, respectively. BMS patients had significantly higher frequencies of GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.001). We also found that 20 (2.3%), 130 (14.7%), and 181 (20.5%) BMS patients and 3 (0.7%), 8 (1.8%), and 6 (1.4%) healthy control subjects had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) organ-specific autoantibody in their sera, respectively. Of 255 TGA/TMA-positive BMS patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 87.8%, 5.1%, and 7.1% of these TGA/TMA-positive BMS patients had normal, lower, and higher serum TSH levels, respectively. Approximately 37.5% of 884 BMS patients have serum GPCA/TGA/TMA positivity. Moreover, 12.3%, 21.6%, and 22.7% of 884 BMS patients have the serum GPCA, TGA, and TMA positivities, respectively. Only 5.1% and 7.1% of TGA/TMA-positive BMS patients have hyperthyroidism and hypothyroidism, respectively. It needs further studies to know whether GPCA-positive BMS patients may finally become as having autoimmune atrophic gastritis. Copyright © 2020 Formosan Medical Association. Published by Elsevier B.V. All rights reserved.

Citation

Chun-Pin Chiang, Yang-Che Wu, Yu-Hsueh Wu, Julia Yu-Fong Chang, Yi-Ping Wang, Andy Sun. Gastric parietal cell and thyroid autoantibodies in patients with burning mouth syndrome. Journal of the Formosan Medical Association = Taiwan yi zhi. 2020 Dec;119(12):1758-1763