A Theoretical Paradigm for Evaluating Risk-Benefit of Status Epilepticus Treatment.

Edilberto Amorim, Chris M McGraw, M Brandon Westover

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 2020 Sep

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Aggressive treatment of status epilepticus with anesthetic drugs can provide rapid seizure control, but it might lead to serious medical complications and worse outcomes. Using a decision analysis approach, this concise review provides a framework for individualized decision making about aggressive and nonaggressive treatment in status epilepticus. The authors propose and review the most relevant parameters guiding the risk-benefit analysis of treatment aggressiveness in status epilepticus and present real-world-based case examples to illustrate how these tools could be used at the bedside and serve to guide future research in refractory status epilepticus treatment.

Citation

Edilberto Amorim, Chris M McGraw, M Brandon Westover. A Theoretical Paradigm for Evaluating Risk-Benefit of Status Epilepticus Treatment. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 2020 Sep;37(5):385-392