Markers in Status Epilepticus Prognosis.

Ayham Alkhachroum, Caroline A Der-Nigoghossian, Clio Rubinos, Jan Claassen

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 2020 Sep

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Status epilepticus (SE) is a neurologic emergency with high morbidity and mortality. The assessment of a patient's prognosis is crucial in making treatment decisions. In this review, we discuss various markers that have been used to prognosticate SE in terms of recurrence, mortality, and functional outcome. These markers include demographic, clinical, electrophysiological, biochemical, and structural data. The heterogeneity of SE etiology and semiology renders development of prognostic markers challenging. Currently, prognostication in SE is limited to a few clinical scores. Future research should integrate clinical, genetic and epigenetic, metabolic, inflammatory, and structural biomarkers into prognostication models to approach "personalized medicine" in prognostication of outcomes after SE.

Citation

Ayham Alkhachroum, Caroline A Der-Nigoghossian, Clio Rubinos, Jan Claassen. Markers in Status Epilepticus Prognosis. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 2020 Sep;37(5):422-428