Alternative Protein Topology-Mediated Evolution of a Catalytic Ribonucleoprotein.

Lien B Lai, Hong-Duc Phan, Walter J Zahurancik, Venkat Gopalan

Trends in biochemical sciences 2020 Oct

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The high-resolution structures of yeast RNase for mitochondrial RNA processing (MRP), a catalytic ribonucleoprotein (RNP), recently reported by Lan et al. and Perederina et al. illustrate how RNA-mediated selection of alternative protein conformations, sampled during stochastic excursions by polymorphic/metamorphic proteins, enabled RNAs and proteins to mutually influence their functional repertoires and shape RNP evolution. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Lien B Lai, Hong-Duc Phan, Walter J Zahurancik, Venkat Gopalan. Alternative Protein Topology-Mediated Evolution of a Catalytic Ribonucleoprotein. Trends in biochemical sciences. 2020 Oct;45(10):825-828