The Anxiolytic Effect of the Neuropeptide Cycloprolylglycine Is Mediated by AMPA and TrkB Receptors.

T A Gudasheva, P Yu Povarnina, K N Koliasnikova, A G Alyaeva, O N Vorontsova, S B Seredenin

Doklady. Biochemistry and biophysics 2020 Jul

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Previously we have shown that the neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors and assumed that the pharmacological effects of CPG are associated with the brain neurotrophic factor. In this paper, we have first demonstrated that DNQX, an inhibitor of AMPA receptors, and K252A, an ihibitor of Trk receptors, prevented the anxiolytic effect of CPG, which confirms the formulated hypothesis.

Citation

T A Gudasheva, P Yu Povarnina, K N Koliasnikova, A G Alyaeva, O N Vorontsova, S B Seredenin. The Anxiolytic Effect of the Neuropeptide Cycloprolylglycine Is Mediated by AMPA and TrkB Receptors. Doklady. Biochemistry and biophysics. 2020 Jul;493(1):190-192