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Various clinical and experimental findings have revealed the causal relationship between autophagy failure and oncogenesis, and several mechanisms have been suggested to explain this relationship. We recently proposed two additional mechanisms: centrosome number dysregulation and the failure of autophagic cell death. Here, we detail the mechanical relationship between autophagy failure and oncogenesis. © 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.


Satoru Torii, Shinya Honda, Michiko Murohashi, Hirofumi Yamaguchi, Shigeomi Shimizu. Autophagy involvement in oncogenesis. Cancer science. 2020 Nov;111(11):3993-3999

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PMID: 32897597

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