Role of the NF-κB system in context-specific tuning of the inflammatory gene response.

Meenakshi Chawla, Payel Roy, Soumen Basak

Current opinion in immunology 2021 Feb

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The canonical NF-κB pathway instructs the expression of inflammatory genes by the RelA:p50 transcription factor in response to diverse cell-activating stimuli. However, this mainstay RelA:p50 transcriptional output must also be curated so as to provide for stimulus-type-specific and cell-type-specific inflammatory responses adapted to the local tissue-microenvironment. Here, we summarize the fundamental mechanisms regulating RelA:p50-mediated gene expressions and discuss how the NF-κB system imparts specificity in the inflammatory gene program. We put forward a conceptual framework where the dynamical attributes and the composition of the nuclear NF-κB complexes cumulatively instruct context-specific inflammatory gene patterns. We propose that integrating mechanistic knowledge and systems-level analyses may offer further insights on NF-κB-mediated inflammatory gene control in the future. Copyright © 2021. Published by Elsevier Ltd.

Citation

Meenakshi Chawla, Payel Roy, Soumen Basak. Role of the NF-κB system in context-specific tuning of the inflammatory gene response. Current opinion in immunology. 2021 Feb;68:21-27