Targeting chromatin dysregulation in organ fibrosis.

Anupama Rani, Chiahsuan Chin, Ross Bremner, Thalachallour Mohanakumar, Sureshbabu Angara

Cytokine & growth factor reviews 2021 Feb

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Fibrosis leads to destruction of organ architecture accompanied by chronic inflammation and loss of function. Fibrosis affects nearly every organ in the body and accounts for ∼45% of total deaths worldwide. Over the past decade, tremendous progress has been made in understanding the basic mechanisms leading to organ fibrosis. However, we are limited with therapeutic options and there is a significant need to develop highly effective anti-fibrotic therapies. Recent advances in sequencing technologies have advanced the burgeoning field of epigenetics towards molecular understanding at a higher resolution. Here we provide a comprehensive review of the recent advances in chromatin regulatory processes, specifically DNA methylation, post-translational modification of histones, and chromatin remodeling complexes in kidney, liver and lung fibrosis. Although this research field is young, we discuss new strategies for potential therapeutic interventions for treating organ fibrosis. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Anupama Rani, Chiahsuan Chin, Ross Bremner, Thalachallour Mohanakumar, Sureshbabu Angara. Targeting chromatin dysregulation in organ fibrosis. Cytokine & growth factor reviews. 2021 Feb;57:64-72