Functions of TopBP1 in preserving genome integrity during mitosis.

TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome segregation. TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. Recently, it has become clear that TopBP1 is repurposed to scaffold different processes dependent on cell cycle regulated changes in phosphorylation of client proteins. Here we review the functions of human TopBP1 in maintaining genome integrity during mitosis. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Jonas Bagge, Vibe H Oestergaard, Michael Lisby. Functions of TopBP1 in preserving genome integrity during mitosis. Seminars in cell & developmental biology. 2021 May;113:57-64

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PMID: 32912640

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