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Many viruses, including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Human Immunodeficiency Virus (HIV), use RNA as their genetic material. How viruses harness RNA structure and RNA-protein interactions to control their replication remains obscure. Recent advances in the characterization of HIV-1 reverse transcriptase, the enzyme that converts its single-stranded RNA genome into a double-stranded DNA copy, reveal how the reverse transcription complex evolves during initiation. Here we highlight these advances in HIV-1 structural biology and discuss how they are furthering our understanding of HIV and related ribonucleoprotein complexes implicated in viral disease. Copyright © 2020. Published by Elsevier Ltd.


Miri Krupkin, Lynnette Nthenya Jackson, Betty Ha, Elisabetta Viani Puglisi. Advances in understanding the initiation of HIV-1 reverse transcription. Current opinion in structural biology. 2020 Dec;65:175-183

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PMID: 32916568

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