Microemulsion systems to enhance the transdermal permeation of ivermectin in dogs: A preliminary in vitro study.

Research in veterinary science 2020 Dec

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This study aims to evaluate the influence of the phase behavior of microemulsions in the transdermal administration ("spot-on") of ivermectin, an antiparasitic drug widely used in the treatment of endoparasites and ectoparasites in dogs. In this regard, pseudoternary phase diagrams composed of water (aqueous phase), isopropyl myristate (oil phase), tween 80 (surfactant) and labrasol (cosurfactant) were obtained in a different surfactant: cosurfactant (S:CS) ratios. S:CS in 1:3 ratio presented a larger region of microemulsion formation and three microemulsions were selected from it and characterized. Subsequently, in vitro permeation and retention studies were conducted using canine skin as membrane. SAXS, rheology and conductivity data were employed to confirm the phase behavior of the microemulsions (w/o, bicontinuous or o/w). The cutaneous permeation and retention tests showed that the w/o microemulsion, followed by bicontinuous microemulsion, resulted in a higher amount of drug permeated through canine skin, suggesting better transdermal permeation. On the other hand, o/w microemulsion resulted in a higher amount of drug accumulated into the skin, suggesting better topical activity. Thus, it can be concluded that phase behavior of microemulsions influenced the drug permeation in the canine skin differently from other animal models. Microemulsions, especially w/o and bicontinuous, can be promising vehicles regarding the transdermal delivery of ivermectin. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Micheline Machado, Isabella Lima Dantas, Juliana Gouveia Galvão, Alyne Dantas Lima, Joyce Kelly Marinheiro da Cunha Gonsalves, Ellen Denise Prado Almeida, Guilherme Rodolfo Souza de Araujo, Leila Bastos Leal, Victor Hugo Vitorino Sarmento, Rogéria Souza Nunes, Ana Amélia Moreira Lira. Microemulsion systems to enhance the transdermal permeation of ivermectin in dogs: A preliminary in vitro study. Research in veterinary science. 2020 Dec;133:31-38