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A chalcone-flavonone type biflavonoid, trichocladabiflavone A (1), along with eight known biflavonoids (2-9) were isolated from the 70% EtOH extract of Selaginella trichoclada. Their structures were elucidated by extensive spectroscopic analyses. Compound 1 was the first chalcone-flavonone type biflavonoid reported in the genus Selaginella. Moreover, compound 1 exhibited moderate cytotoxicity against DU145, MCF-7 and PC3 human cancer cell lines.


Yang Xie, Xiao-Chang Yao, Lei-Hong Tan, Hong-Ping Long, Ping-Sheng Xu, Jing Li, Gui-Shan Tan. Trichocladabiflavone A, a chalcone-flavonone type biflavonoid from Selaginella trichoclada Alsto. Natural product research. 2022 Apr;36(7):1797-1802

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PMID: 32924604

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